VOLUME 72 : 2024

Association of MTNR1B rs10830963 C>G Polymorphism with the risk of Gestational Diabetes Mellitus: An Updated Meta-analysis

PAGE 18-32

Online Publication Date: April 2024

Joe Anthony H. Manzano, Sasha Mikole Gutierrez, Marlan T. Magdalaga, Omar A. Albuaimi and John Donnie A. Ramos

Gestational diabetes mellitus (GDM) is one of the metabolic disorders of pregnancy that result in short-
and long-term adverse outcomes to both the mothers and her offspring. Among the factors linked to

GDM susceptibility, genetic variations such as single nucleotide polymorphisms (SNPs) are the most
implicated. Several case-control association studies have reported that the G allele of SNP rs10830963
in the melatonin receptor 1B (MTNR1B) is associated with higher GDM risk, however others reported
insignificant associations. Previous meta-analyses also showed inconsistent findings. Herein, we
performed a comprehensive literature search and meta-analysis to clarify the role of the SNP on GDM
risk. Pooled odds ratios (ORs) with 95% CI were calculated to measure the strength of the association.
Meta-analysis of the overall population using 11 eligible studies with a total of 4760 GDM cases and 5345
controls revealed significant association with the variant G allele and increased risk of GDM (CC vs. CG:
OR = 1.28, 95% CI = 1.17−1.41, P < 0.001; CC vs. GG: OR = 1.92, 95% CI = 1.49−2.49, P < 0.001; C vs.
G: OR = 1.30, 95% CI = 1.16−1.46, P < 0.001).


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