John P. Paulin, Regina Belen P. Callanta, Mario A. Tan, Maria Cristina R. Ramos, & Mafel C. Ysrael
The stem bark of Scyphiphora hydrophyllacea was evaluated for a-glucosidase inhibitory activity. The lyophilized expressed juice of S. hydrophyllacea was found to exhibit a-glucosidase inhibition with an IC50 of 8.63 ± 2.16 μg/mL. The fractions of S. hydrophyllacea were also found to inhibit the α- glucosidase with the n-butanol fraction being the most active (IC50 2.24 ± 0.75 μg/mL). Bioassay-guided isolation of the active constituent from the n-butanol fraction afforded the isolation and structure elucidation of a new iridoid glycoside named scyphiphoroid (1) with an IC50 2.40 ± 0.29 μg/mL.
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