VOLUME 62 : 2014

VOLUME 62 : 2014

ACTA MANILANA publishes research and innovation in the different branches of the natural and applied sciences. It reports significant development in the discipline, and novel applications, unconfined by the traditional coverage of the disciplines.

Anti-inflammatory and antimicrobial constituents from the leaves of Villaria odorata

Page 47-52

Mario A. Tan, Regina Belen P. Callanta, Carlo Chris S. Apurillo, Thomas Edison E. dela Cruz, Grecebio Jonathan D. Alejandro, & Mafel C. Ysrael

Graphical Abstract


Three iridoids (1–3) and a sesquiterpenoid (4) were isolated from the leaves of Villaria odorata, a Philippine endemic Rubiaceae species. The structures were elucidated based on NMR and MS and in comparison with the literature. The anti-inflammatory activity of 1– 4 was evaluated against COX-II, while the MIC and MBC of 3 and 4 were determined using the microtiter plate dilution assay.

Keywords: Rubiaceae, Villaria, antiinflammatory, antimicrobial, MIC, MBC, COX-II


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